<?xml version="1.0" encoding="UTF-8"?><rss version="2.0"
	xmlns:content="http://purl.org/rss/1.0/modules/content/"
	xmlns:dc="http://purl.org/dc/elements/1.1/"
	xmlns:atom="http://www.w3.org/2005/Atom"
	xmlns:sy="http://purl.org/rss/1.0/modules/syndication/"
	xmlns:georss="http://www.georss.org/georss" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:media="http://search.yahoo.com/mrss/"
		>
<channel>
	<title>Comments on: Holford believes Secretin is &quot;Worth considering&quot; as an autism treatment; however, there is no evidence that this treatment is effective</title>
	<atom:link href="http://holfordwatch.info/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/feed/" rel="self" type="application/rss+xml" />
	<link>http://holfordwatch.info/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/</link>
	<description>The truth about Patrick Holford, media nutritionist</description>
	<lastBuildDate>Fri, 14 Oct 2011 15:11:39 +0000</lastBuildDate>
	<sy:updatePeriod>hourly</sy:updatePeriod>
	<sy:updateFrequency>1</sy:updateFrequency>
	<generator>http://wordpress.com/</generator>
	<item>
		<title>By: Andrew Wakefield Lodges Complaint About Brian Deer with Press Complaints Commission &#171; Holford Watch: Patrick Holford, nutritionism and bad science</title>
		<link>http://holfordwatch.info/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/comment-page-1/#comment-17095</link>
		<dc:creator><![CDATA[Andrew Wakefield Lodges Complaint About Brian Deer with Press Complaints Commission &#171; Holford Watch: Patrick Holford, nutritionism and bad science]]></dc:creator>
		<pubDate>Mon, 16 Mar 2009 11:53:58 +0000</pubDate>
		<guid isPermaLink="false">http://holfordwatch.wordpress.com/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/#comment-17095</guid>
		<description><![CDATA[[...] for the &#8220;adequate care&#8221; on offer - Secretin has been examined as a treatment intervention and found wanting. Ditto, there is no clinical support for the masses of supplements and the &#8216;healing [...]]]></description>
		<content:encoded><![CDATA[<p>[...] for the &#8220;adequate care&#8221; on offer &#8211; Secretin has been examined as a treatment intervention and found wanting. Ditto, there is no clinical support for the masses of supplements and the &#8216;healing [...]</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Patrick Holford Promotes Error: Does This Explain His Continuing Support for Opposing MMR and Supporting Andrew Wakefield&#8217;s Research? &#171; Holford Watch: Patrick Holford, nutritionism and bad science</title>
		<link>http://holfordwatch.info/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/comment-page-1/#comment-15158</link>
		<dc:creator><![CDATA[Patrick Holford Promotes Error: Does This Explain His Continuing Support for Opposing MMR and Supporting Andrew Wakefield&#8217;s Research? &#171; Holford Watch: Patrick Holford, nutritionism and bad science]]></dc:creator>
		<pubDate>Sun, 22 Feb 2009 19:58:52 +0000</pubDate>
		<guid isPermaLink="false">http://holfordwatch.wordpress.com/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/#comment-15158</guid>
		<description><![CDATA[[...] some entrepreneurs to sell unevidenced diagnostic tests (both Wakefield and Holford continue to support the use of Secretin despite not only the absence of efficacy but the indication that it may be less efficacious than a [...]]]></description>
		<content:encoded><![CDATA[<p>[...] some entrepreneurs to sell unevidenced diagnostic tests (both Wakefield and Holford continue to support the use of Secretin despite not only the absence of efficacy but the indication that it may be less efficacious than a [...]</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Shinga</title>
		<link>http://holfordwatch.info/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/comment-page-1/#comment-273</link>
		<dc:creator><![CDATA[Shinga]]></dc:creator>
		<pubDate>Mon, 25 Jun 2007 08:17:53 +0000</pubDate>
		<guid isPermaLink="false">http://holfordwatch.wordpress.com/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/#comment-273</guid>
		<description><![CDATA[I had a quick flick through the references in that last mercury poisoning paper. I see that most of those references are to methylmercury.&lt;br/&gt;&lt;br/&gt;Ethyl alcohol (ethanol) widely consumed. You may experience a wide variety of effects at small doses but adapt rapidly to the point where you can adapt to large doses.&lt;br/&gt;&lt;br/&gt;Methyl alcohol. Very much more likely to kill you in doses as low as teaspoons.&lt;br/&gt;&lt;br/&gt;Alcohol v. methanol (wood alcohol).&lt;br/&gt;&lt;br/&gt;The same difference between ethylmercury and methylmercury. You can not extrapolate from methylmercury to ethylmercury.&lt;br/&gt;&lt;br/&gt;To paraphrase Father Ted on the issue of perspective: &quot;these cows are near. Those (gestures to field) are far away. Near. Far away&quot;.]]></description>
		<content:encoded><![CDATA[<p>I had a quick flick through the references in that last mercury poisoning paper. I see that most of those references are to methylmercury.</p>
<p>Ethyl alcohol (ethanol) widely consumed. You may experience a wide variety of effects at small doses but adapt rapidly to the point where you can adapt to large doses.</p>
<p>Methyl alcohol. Very much more likely to kill you in doses as low as teaspoons.</p>
<p>Alcohol v. methanol (wood alcohol).</p>
<p>The same difference between ethylmercury and methylmercury. You can not extrapolate from methylmercury to ethylmercury.</p>
<p>To paraphrase Father Ted on the issue of perspective: &#8220;these cows are near. Those (gestures to field) are far away. Near. Far away&#8221;.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Jon</title>
		<link>http://holfordwatch.info/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/comment-page-1/#comment-272</link>
		<dc:creator><![CDATA[Jon]]></dc:creator>
		<pubDate>Sun, 24 Jun 2007 19:53:02 +0000</pubDate>
		<guid isPermaLink="false">http://holfordwatch.wordpress.com/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/#comment-272</guid>
		<description><![CDATA[Thanks Shinga.  The closest thing to a reference given by Holford is a URL for the homepage of the &lt;a HREF=&quot;http://www.autism.com/ari/&quot; REL=&quot;nofollow&quot;&gt;Autism Research Institute&#039;s website&lt;/a&gt;.  The Institute is involved in Defeat Autism Now!, and the website has a frankly scary array of weird and wonderful treatments which they push (sorry - maybe I should say &#039;suggest&#039;) for autism.&lt;br/&gt;&lt;br/&gt;Holford doesn&#039;t specify which report on the site shows that secretin is worth considering.  What I have seen, though, does not fill me with confidence as to their research quality.&lt;br/&gt;&lt;br/&gt;For example, The Institute have come up with an impressively novel excuse (I can&#039;t bring myself to say &#039;hypothesis&#039;) as to why secretin is shown to be an ineffective autism treatments in double-blind RCTs: a &quot;&lt;a HREF=&quot;http://www.autism.com/ari/newsletter/v142/page3.pdf&quot; REL=&quot;nofollow&quot;&gt;negative placebo effect&lt;/a&gt;&quot;.  I was trying to get a sense of the Institute&#039;s response to the trials which show secretin to be ineffective, but the closest thing I could find was a &lt;a HREF=&quot;http://www.autism.com/ari/newsletter/v181/page3.pdf&quot; REL=&quot;nofollow&quot;&gt;letter from Rimlaud&lt;/a&gt;.&lt;br/&gt;&lt;br/&gt;One more nugget from the Institute&#039;s website that I think is worth posting: they do discuss &lt;a HREF=&quot;http://www.autism.com/ari/editorials/ed_safety.htm&quot; REL=&quot;nofollow&quot;&gt;safety concerns about secretin&lt;/a&gt;.  While trying to argue &lt;i&gt;in favour&lt;/i&gt; of its use, the Institute&#039;s article states that: &quot;It is possible that the problems described above [when secretin was administered] may not be caused by secretin but instead by the panic and stress experienced by a child who is held down by adults while an IV needle is inserted.&quot;  I hope I&#039;m not alone in finding the idea of a child being caused considerable distress - by being held down so that an IV dose of an ineffective drug could be administered - rather disturbing.&lt;br/&gt;&lt;br/&gt;I could have done some kind of survey of the Institute&#039;s research - but it already feels as if this &#039;research&#039; has been using my eyeballs as a tool to beat me over the head.  And, to be honest, if Holford doesn&#039;t go to the effort of referring to which part of the Institute&#039;s (big, hard to navigate) website supposedly backs up his view, I can&#039;t be bothered to inflict reading this whole website on myself.&lt;br/&gt;&lt;br/&gt;One more thing re. the Institute - the article they carry on how autism is a type of mercury poisoning is a wonderfully Orwellian attempt to ignore the inconvenient facts about these two conditions.  The table &lt;a HREF=&quot;http://www.autism.com/triggers/vaccine/mercurylong.htm#iv&quot; REL=&quot;nofollow&quot;&gt;explaining how the symptoms of autism are the same as the symptoms of mercury poisoning&lt;/a&gt;, in particular, would be rather funny, if these people weren&#039;t advocating certain &#039;treatments&#039; for children.  Off-topic, I know, but the article is such a classic I thought it would be worth sharing...]]></description>
		<content:encoded><![CDATA[<p>Thanks Shinga.  The closest thing to a reference given by Holford is a URL for the homepage of the <a HREF="http://www.autism.com/ari/" REL="nofollow">Autism Research Institute&#8217;s website</a>.  The Institute is involved in Defeat Autism Now!, and the website has a frankly scary array of weird and wonderful treatments which they push (sorry &#8211; maybe I should say &#8216;suggest&#8217;) for autism.</p>
<p>Holford doesn&#8217;t specify which report on the site shows that secretin is worth considering.  What I have seen, though, does not fill me with confidence as to their research quality.</p>
<p>For example, The Institute have come up with an impressively novel excuse (I can&#8217;t bring myself to say &#8216;hypothesis&#8217;) as to why secretin is shown to be an ineffective autism treatments in double-blind RCTs: a &#8220;<a HREF="http://www.autism.com/ari/newsletter/v142/page3.pdf" REL="nofollow">negative placebo effect</a>&#8220;.  I was trying to get a sense of the Institute&#8217;s response to the trials which show secretin to be ineffective, but the closest thing I could find was a <a HREF="http://www.autism.com/ari/newsletter/v181/page3.pdf" REL="nofollow">letter from Rimlaud</a>.</p>
<p>One more nugget from the Institute&#8217;s website that I think is worth posting: they do discuss <a HREF="http://www.autism.com/ari/editorials/ed_safety.htm" REL="nofollow">safety concerns about secretin</a>.  While trying to argue <i>in favour</i> of its use, the Institute&#8217;s article states that: &#8220;It is possible that the problems described above [when secretin was administered] may not be caused by secretin but instead by the panic and stress experienced by a child who is held down by adults while an IV needle is inserted.&#8221;  I hope I&#8217;m not alone in finding the idea of a child being caused considerable distress &#8211; by being held down so that an IV dose of an ineffective drug could be administered &#8211; rather disturbing.</p>
<p>I could have done some kind of survey of the Institute&#8217;s research &#8211; but it already feels as if this &#8216;research&#8217; has been using my eyeballs as a tool to beat me over the head.  And, to be honest, if Holford doesn&#8217;t go to the effort of referring to which part of the Institute&#8217;s (big, hard to navigate) website supposedly backs up his view, I can&#8217;t be bothered to inflict reading this whole website on myself.</p>
<p>One more thing re. the Institute &#8211; the article they carry on how autism is a type of mercury poisoning is a wonderfully Orwellian attempt to ignore the inconvenient facts about these two conditions.  The table <a HREF="http://www.autism.com/triggers/vaccine/mercurylong.htm#iv" REL="nofollow">explaining how the symptoms of autism are the same as the symptoms of mercury poisoning</a>, in particular, would be rather funny, if these people weren&#8217;t advocating certain &#8216;treatments&#8217; for children.  Off-topic, I know, but the article is such a classic I thought it would be worth sharing&#8230;</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Shinga</title>
		<link>http://holfordwatch.info/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/comment-page-1/#comment-271</link>
		<dc:creator><![CDATA[Shinga]]></dc:creator>
		<pubDate>Sun, 24 Jun 2007 18:30:47 +0000</pubDate>
		<guid isPermaLink="false">http://holfordwatch.wordpress.com/2007/06/24/holford-believes-secretin-is-worth-considering-as-an-autism-treatment-however-there-is-no-evidence-that-this-treatment-is-effective/#comment-271</guid>
		<description><![CDATA[I&#039;m having severe misgivings about some of the quality of the research if it is leading to recommendations that secretin is &quot;worth considering&quot;. It is hard to accept that as a reasonable outcome of a comprehensive survey of the literature.]]></description>
		<content:encoded><![CDATA[<p>I&#8217;m having severe misgivings about some of the quality of the research if it is leading to recommendations that secretin is &#8220;worth considering&#8221;. It is hard to accept that as a reasonable outcome of a comprehensive survey of the literature.</p>
]]></content:encoded>
	</item>
</channel>
</rss>

